Die Alzheimer-Krankheit: Quecksilber als pathogener Faktor und Apolipoprotein E als Moderator
Joachim Mutter1, Johannes Naumann1, Catharina Sadaghiani1, Rainer Schneider1,2 und Harald Walach1,2,3
The etiology of most cases of Alzheimers disease (AD) is as yet unknown.
Epidemiological studies suggest that environmental factors may be involved beside genetic risk factors. Some studies have shown higher mercury concentrations in brains of deceased and in blood of living patients with Alzheimers disease. Experimental studies have found that even smallest amounts of mercury but no other metals in low concentrations were able to cause all nerve cell changes, which are typical for Alzheimers disease. The most important genetic risk factor for sporadic Alzheimers disease is the presence of the apolipoprotein Ee4 allele whereas the apolipoprotein Ee2 allele reduces the risk of developing Alzheimers disease. Some investigators have suggested that apolipoprotein Ee4 has a reduced ability to bind metals like mercury and therefore explain the higher risk for Alzheimers disease. Therapeutic approaches embrace pharmaceuticals which bind metals in the brain of patients with Alzheimers disease.
In sum, both the findings from epidemiological and demographical studies, the frequency of amalgam application in industrialized countries, clinical studies, experimental studies and the dental state of AD patients in comparison to controls suggest a decisive role for inorganic mercury in the etiology of AD.
umwelt-medizin-gesellschaft 18 (4): 294-301
Autoren: 1Institut für Umweltmedizin und Krankenhaushygiene, Universitätsklinik Freiburg, 2Samueli Institute, European Office, Freiburg, 3School for Social Sciences, University College Northampton
Korrespondenzadresse: Dr. med. Joachim Mutter, Uni-Zentrum Naturheilkunde Freiburg, Institut für Umweltmedizin und Hygiene, Universitätsklinikum, Breisacherstr. 60, 79106 Freiburg, Tel. + Fax: ++49 (0)761/270548-4(-9), firstname.lastname@example.org, http://www.uni-zentrum-naturheilkunde.de